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Gender may influence antidepressant AD treatment outcome.

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In our chronic study, hormone pellets containing E2 and P were administered to OVX animals to produce proestrus phase levels of these hormones. This is of some interest as estrogen has been shown to modulate neurotransmitter systems, including serotonergic and noradrenergic systems that are involved in mood regulation McEwen and Alves ; Rubinow et al. Brain Res. Support Center Support Center.

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Gender issues in depression. Reduction in the latency of action of antidepressants by 17 beta-estradiol in the forced swimming test.

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